Data from: FSHB transcription is regulated by a novel 5’ distal enhancer containing a fertility-associated single nucleotide polymorphism

Stephanie C. Bohaczuk, Varykina G. Thackray, Jia Shen, Dorota Skowronska-Krawczyk & Pamela L. Mellon
The pituitary gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone, signal the gonads to regulate male and female fertility. FSH is critical for female fertility as it regulates oocyte maturation, ovulation, and hormone synthesis. Multiple genome-wide association studies (GWAS) link a 130 Kb locus at 11p14.1, which encompasses the FSH beta-subunit (FSHB) gene, with fertility-related traits including polycystic ovary syndrome, age of natural menopause, and dizygotic twinning. The most statistically significant single-nucleotide polymorphism from several GWAS...
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