Growth hormone pulses are differentially regulated by the circadian clock gene Bmal1

Erica Schoeller, Karen Tonsfeldt, McKenna Sinkovich, Ruijing Shi & Pamela Mellon
In this study, we found that loss of the circadian clock gene Bmal1 causes disruptions throughout the growth hormone (GH) axis, from hepatic gene expression to production of urinary pheromones and pheromone-dependent behavior. First, we show that Bmal1 knockout (KO) males elicit reduced aggressive responses from WT males and secrete lower levels of major urinary proteins (MUPs); however, we also found that a liver-specific KO of Bmal1 (Liver-Bmal1-KO) produces a similar reduction in MUP secretion...
1 citation reported since publication in 2020.
17 views reported since publication in 2020.

These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
What does this mean?
4 downloads reported since publication in 2020.

These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
What does this mean?