Cerebellar Physiological Abnormalities in the 15q11-13 Duplication and CYFIP1 Overexpressing Murine Models of Autism Spectrum Disorder

Dana Simmons
Autism Spectrum Disorders (ASD) present a range of symptoms including abnormal social interactions, increased perseverative behaviors, and difficulty with communication. Despite the many studies on these classical symptoms, many patients also display underestimated motor symptoms. Motor symptoms such as impaired motor learning during eyeblink conditioning, as well as difficulty with eye movements and unstable gait or coordination, are strong evidence for cerebellar involvement in the pathology of ASD. Eyeblink conditioning is dependent on an intact,...
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