Identification of a Superfamily of Membrane Protein Biogenesis Factors

Stefan Andrei Anghel
Cells possess specialized machinery to direct the insertion of membrane proteins into the lipid bilayer. In all organisms, the Sec61/SecYEG channel inserts most membrane proteins into the membrane in concert with various accessory subunits. Additionally, other membrane protein insertion systems have been described. In bacteria, the essential protein YidC inserts certain proteins into the plasma membrane. Eukaryotic orthologs of YidC are present in the mitochondrial inner membrane and the chloroplast thylakoid membrane (where they are...
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