High-Resolution Mapping of mRNA Modifications

Lisheng Zhang
Transcriptome carries a wide range of different chemical modifications. Among these modifications, RNA methylation is the most abundant, exerting important functions in multiple biological processes in eukaryotes. Especially, the recent discoveries of N6-methyladenosine (m6A) in transcriptome with reversible dynamics and regulatory roles have drawn considerable attentions from world-wide scientists. While N6-methyladenosine (m6A) is widely observed to regulate gene expression in mammals, our lab has also reasoned that positively-charged mRNA modifications such as N1-methyladenosine (m1A) could...
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