Genetic and Genomic Approaches to Investigate the Roles of Cis-regulatory Elements in Development and Disease

Lindsey Elizabeth Montefiori
Gene regulation describes the totality of molecular events that result in precisely orchestrated gene expression patterns which collectively drive organismal development and define cellular states. Much of this logic is encoded in the genome itself, which is subject to mutation and natural variation. Because of the fundamental role that gene regulation plays in cellular biology, perturbations to gene expression patterns may have pathophysiological consequences, and these are far from being well understood. In my dissertation...
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