Distinct Cell Death Sensitivity and Adaptivity in T Cell Subsets Following Manipulation of the BCL-2 Family of Proteins

Lindsey Michelle Ludwig
The BCL-2 family comprises an essential network of proteins that govern a cell’s decision to live or die. An increasingly diverse number of BH3 mimetics have been developed to manipulate interactions between BCL-2 family proteins within diseased and normal cells. Based on lymphocyte dependency on these proteins for ontogeny and survival, we hypothesized that T cells would have unique differences in their BCL-2 repertoire at baseline and in response to BH3 mimetic treatment. Long-term targeting...
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