Aberrant Synaptic Plasticity Underlying Parkinsonian Motor Behaviors

Meera Janak Patel
The long-lasting deterioration of motor output in Parkinson’s disease (PD) is thought to arise from the degeneration of midbrain dopamine neurons and the subsequent loss of dopamine signaling in the striatum. While much is already known about dopaminergic modulation of striatal activity, few studies have directly linked aberrant synaptic plasticity to PD motor symptoms. Here, I examine the striatal synaptic plasticity mechanisms that contribute to parkinsonian motor behaviors. To establish a technique for examining plasticity...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.