Constructing Chromatin through Multiscale Simulations: A Nucleosome-Centric Approach

Joshua J Moller
Chromatin is a hierarchically structured fiber that regulates gene expression. Consisting of a complex network of DNA and proteins, chromatin is host to dynamic modes that facilitate genomic packaging. A comprehensive description of chromatin structure and dynamics is invaluable for a fundamental understanding of how inheritable genetic diseases originate. We now know that genetic diseases can result from epigenomic phenomena which alter the thermodynamics of the nucleosome, the fundamental unit of chromatin. Therefore, it is...
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