Immune Mechanisms Maintaining Transplantation Tolerance

Christine Maria McIntosh
While the development of powerful immunosuppressive medications enabled the use of organ transplantation as a treatment for end-stage organ failure, current immunosuppression protocols drive many co-morbidities; thus, they now present a critical limitation to long-term health and quality of life for transplant recipients. Replacing conventional immunosuppression with treatments to induce donor-specific immune tolerance would eliminate life-long exposure to drug toxicity and high risk of severe infections and malignancies for transplant recipients. Therefore, a large amount...
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