Investigating the Dynamics of Gene Regulation during Cardiomyocyte Differentiation Using Bulk and Single Cell RNA Sequencing

Reem Elorbany
Genetic variants that alter gene regulation play a crucial role in the genetics of human development and disease. Although genome-wide association studies have found thousands of genetic loci associated with complex phenotypes, a substantial fraction of these trait-associated loci remain unexplained. Gene regulatory effects are context-specific and can result in dynamic gene expression changes over time and across cell types. To enhance our understanding of the genetic architecture of complex traits in a dynamic context,...
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