CXCR4 Regulates B Cell Receptor Editing

Michael K Okoreeh
During B lymphopoiesis, B cell progenitors progress through alternating and mutually exclusive stages of clonal expansion and immunoglobulin (Ig) gene rearrangements. Great diversity is generated through the stochastic recombination of Ig gene segments encoding heavy and light chain variable domains. However, this commonly generates autoreactivity. Previous studies have shown that receptor editing is the predominant central tolerance mechanism for self-reactive B cells in the bone marrow. Receptor editing rescues autoreactive B cells from negative selection,...
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