Tumor Cell-Intrinsic Defects in STING Pathway Signaling and Type I Interferon Expression

Blake Alan Flood
It has previously been shown that immunogenic tumors spontaneously activate the innate immune system through the STING pathway. Based on this observation, STING agonists have been developed and are being tested as a pharmacologic approach to activate the pathway and promote anti-tumor immunity. As part of these studies, we observed that tumor cells themselves usually fail to produce IFN-β in response to STING agonists or cytoplasmic DNA, arguing that loss of activation of this pathway...
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