Developing Polymeric Materials for Immunoengineering

Ruyi Wang
In this thesis, we developed three polymer-based drug delivery platforms to address three health problems: oral immunotherapy for food allergy, tolerance against protein-based therapeutics, and tumor target therapy. As a major commensal bacterial metabolite, butyrate showed protective effect to the gut immunity and suppressed the activation of antigen presenting cells. However, there is an unmet need of developing an efficient formulation to deliver butyrate to either gastrointestinal (GI) tract or draining lymph nodes. In order...
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