Insights Into Gene Regulation and Disease at Obesity GWAS Loci

Amelia Christine Joslin
While genome-wide association studies (GWAS) have identified variants and genes associated with human disease, a comprehensive understanding of the genetic architecture of individual loci and the functional implications of these associations remains incomplete. In this work, we applied an integrated pipeline to chart the regulatory landscapes of obesity-associated loci within two cell types central to obesity etiology. In both adipocytes and hypothalamic neurons, we annotated gene expression, chromatin accessibility, and long-range chromatin interactions across multiple...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.