Furthering Understanding of T and CAR-T Cell Differentiation Using Cutting-Edge Sequencing and Imaging Technologies

Guoshuai Cao
Fundamental questions in T cell differentiation remain unanswered: 1) EZH2’s role in Tfh fate commitment; 2) differences of TEX differentiation in Tumor and in Chronic infection; 3) CAR-T cells post-infusion differentiation. Besides, there is no high-dimensional quantitative analysis and machine learning pipeline for TCR signaling studies. This thesis work addressed these issues using advanced sequencing and imaging technologies. Firstly, using ATAC-seq, we found that EZH2-mediated H3K27me3 modifications regulate early Tfh fate commitment, but not late...
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