Development of Palladium-Catalyzed Arene Difunctionalization Reactions Enabled by Norbornene

Alexander Joseph Rago
In this thesis, various approaches from the literature employing carbon–hydrogen bond activation for the synthesis of indoles and their close derivatives, indolines and carbazoles, have been discussed. Palladium/norbornene cooperative catalysis, in particular, presents an attractive platform for the preparation of indoles via the regioselective difunctionalization of an aryl halide and its unactivated ortho-carbon–hydrogen bond. The detailed development of a synthetic strategy for the preparation of indoles using this catalytic duo via an ortho-amination, ipso-Heck cyclization...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.