Interplay of Structure, Mechanics, and Dynamics in Reconstituted Actin

Danielle Robin Scheff
Cells dynamically control their material properties through remodeling of the actin cytoskeleton, an assembly of cross-linked networks and bundles formed from the biopolymer actin. Actin thus serves as an ideal model system to study mechanical adaptation of the cytoskeleton towards understanding both the functioning of cells and inform the creation of novel materials. In this work, I reconstitute networks in vitro to investigate the interplay of three aspects of actin: structure, mechanical properties, and dynamics.First,...
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