The Development of Acrylamide-based Inhibitors of DHHC Family Proteins to Regulate ERK Acylation and Activity

Saara-Anne Azizi
Protein S-acylation, an enzymatically modulated lipid post-translational modification, is frequent and consequential; at the cellular level, it regulates protein subcellular trafficking and signaling activity, and at the organismal level, has been implicated in cancer and neurologic and inflammatory disease. However, the impact of dynamic S-acylation for many proteins remains unknown, in part due to lack of inhibitors for the enzymes that catalyze lipid addition, the DHHC family proteins. Not only is the most commonly used...
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