Defining Leukemogenic Mechanisms in Hereditary Hematopoietic Malignancies

Michael William Drazer
Hereditary hematopoietic malignancies (HHMs) were once thought to be exceedingly rare, but the development of relatively inexpensive next generation sequencing (NGS) in the early 21st century led to a dramatic increase in the number of recognized HHM syndromes. Now, HHMs are an accepted entity in the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia, and a substantial proportion of individuals are recognized to be at risk for these syndromes. However, a number...
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