Understanding and Overcoming the Non-T cell-inflamed Tumor Microenvironment

Emily Faye Higgs
Checkpoint blockade immunotherapies have demonstrated remarkable therapeutic success by overcoming tumor-induced T cell inhibition, however their efficacy is poor when patients lack evidence of a spontaneous T cell response. Tumors in mice which generate a spontaneous T cell response activate the innate immune system through the STING pathway. STING agonists promote dendritic cell (DC) activation as well as subsequent priming and recruitment of T cells, leading to significant tumor control in transplantable models. However, preliminary...
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