Central immunological position of the human histo (blood) group O(H).

Peter Arend
Prokaryotic "blood group A/B-like" antigenic structures basically induce cross-reactive anti-A/B immunoglobulins, which neither arise in blood group A nor in B individuals due to clonal selection but occur predominantly or exclusively in blood group O. While bacterial endotoxins non-specifically stimulate the formation of all immunoglobulins, involving the anti-A/B isoagglutinins, a definite, adaptive immunological induction of these agglutinins appears to be restricted to blood group O(H) individuals. In the non-O blood groups, anti-A/B reactivity is exerted...

1 Related Work

Central immunological position of the human histo (blood) group O(H) phenotype.

Peter Arend
Abstract. While blood group A phenotype development is associated with impaired formation of adaptive and innate immunoglobulins due to clonal selection and phenotypic, glycosidic accommodation of plasma proteins, it is significantly burdened with an increased risk of developing certain types of cancer, while exerting strong susceptibility to severe malaria infection. Both the risk of developing cancer and the susceptibility to malaria appear molecularly to be strongly related to phenotype formation, in which the blood group...

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Publication Year

  • 2017
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  • figshare Academic Research System
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