Central immunological position of the human histo (blood) group O(H).

Peter Arend
Prokaryotic "blood group A/B-like" antigenic structures basically induce cross-reactive anti-A/B immunoglobulins, which neither arise in blood group A nor in B individuals due to clonal selection but occur predominantly or exclusively in blood group O. While bacterial endotoxins non-specifically stimulate the formation of all immunoglobulins, involving the anti-A/B isoagglutinins, a definite, adaptive immunological induction of these agglutinins appears to be restricted to blood group O(H) individuals. In the non-O blood groups, anti-A/B reactivity is exerted...

1 Related Work

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
Development of the blood group A phenotype is associated with the impaired formation of adaptive and innate immunoglobulins due to clonal selection and phenotypic, glycosidic accommodation of plasma proteins. Compared with individuals with blood group O(H), individuals with blood group A have a significantly higher risk of developing certain types of cancer and exhibit strong susceptibility to malaria tropica or infection by Plasmodium falciparum. Although malaria tertiana, caused by Plasmodium vivax, is the best documented...

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  • 2017
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