Central immunological position of the human histo (blood) group O(H).

Peter Arend
Prokaryotic "blood group A/B-like" antigenic structures basically induce cross-reactive anti-A/B immunoglobulins, which neither arise in blood group A nor in B individuals due to clonal selection but occur predominantly or exclusively in blood group O. While bacterial endotoxins non-specifically stimulate the formation of all immunoglobulins, involving the anti-A/B isoagglutinins, a definite, adaptive immunological induction of these agglutinins appears to be restricted to blood group O(H) individuals. In the non-O blood groups, anti-A/B reactivity is exerted...

309 Related Works

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease

Peter Arend
The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, and the blood group antigen A represents the ancestral primordial structure, while under the selective pressure of life-threatening diseases blood group O(H) came to dominate as the most common blood group worldwide. Non-O(H) phenotypes demonstrate impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Compared with individuals with blood...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease

Peter Arend
The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, and the blood group antigen A represents the ancestral primordial structure, while under the selective pressure of life-threatening diseases blood group O(H) came to dominate as the most common blood group worldwide. Non-O(H) phenotypes demonstrate impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Compared with individuals with blood...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease

Peter Arend
The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, and the blood group antigen A represents the ancestral primordial structure, while under the selective pressure of life-threatening diseases blood group O(H) came to dominate as the most common blood group worldwide. Non-O(H) phenotypes demonstrate impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Compared with individuals with blood...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease

Peter Arend
The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, and the blood group antigen A represents the ancestral primordial structure, while under the selective pressure of life-threatening diseases blood group O(H) came to dominate as the most common blood group worldwide. Non-O(H) phenotypes demonstrate impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Compared with individuals with blood...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease

Peter Arend
The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, and the blood group antigen A represents the ancestral primordial structure, while under the selective pressure of life-threatening diseases blood group O(H) came to dominate as the most common blood group worldwide. Non-O(H) phenotypes demonstrate impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Compared with individuals with blood...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, and the blood group antigen A represents the ancestral primordial structure, while under the selective pressure of life-threatening diseases blood group O(H) came to dominate as the most common blood group worldwide. Non-O(H) phenotypes demonstrate impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Compared with individuals with blood...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, and the blood group antigen A represents the ancestral primordial structure, while under the selective pressure of life-threatening diseases blood group O(H) came to dominate as the most common blood group worldwide. Non-O(H) phenotypes demonstrate impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Compared with individuals with blood...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but they originated in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Indeed, compared with individuals with blood group O(H), blood group A individuals not only have a significantly higher...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but they originated in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Indeed, compared with individuals with blood group O(H), blood group A individuals not only have a significantly higher...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but they originated in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Indeed, compared with individuals with blood group O(H), blood group A individuals not only have a significantly higher...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but they originated in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Indeed, compared with individuals with blood group O(H), blood group A individuals not only have a significantly higher...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but they originated in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Indeed, compared with individuals with blood group O(H), blood group A individuals not only have a significantly higher...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but they originated in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Indeed, compared with individuals with blood group O(H), blood group A individuals not only have a significantly higher...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but they originated in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Indeed, compared with individuals with blood group O(H), blood group A individuals not only have a significantly higher...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but they originated in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Indeed, compared with individuals with blood group O(H), blood group A individuals not only have a significantly higher...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but they originated in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Indeed, compared with individuals with blood group O(H), blood group A individuals not only have a significantly higher...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but they originated in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Indeed, compared with individuals with blood group O(H), blood group A individuals not only have a significantly higher risk...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but they originated in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Indeed, compared with individuals with blood group O(H), blood group A individuals not only have a significantly higher risk...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but they originated in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Indeed, compared with individuals with blood group O(H), blood group A individuals not only have a significantly higher risk...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but they originated in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Indeed, compared with individuals with blood group O(H), blood group A individuals not only have a significantly higher risk...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but they originated in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Indeed, compared with individuals with blood group O(H), blood group A individuals not only have a significantly higher risk...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but arise in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with the impaired formation of adaptive and innate immunoglobulin specificities. Indeed, compared with individuals with blood group O(H), individuals with blood group A not only have significantly higher risk of developing certain types of cancer but also exhibit strong...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but arise in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with the impaired formation of adaptive and innate immunoglobulin specificities. Indeed, compared with individuals with blood group O(H), individuals with blood group A not only have significantly higher risk of developing certain types of cancer but also exhibit strong...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but arise in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with the impaired formation of adaptive and innate immunoglobulin specificities. Indeed, compared with individuals with blood group O(H), individuals with blood group A not only have significantly higher risk of developing certain types of cancer but also exhibit strong...

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but arise in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with the impaired formation of adaptive and innate immunoglobulin specificities. Indeed, compared with individuals with blood group O(H), individuals with blood group A not only have significantly higher risk of developing certain types of cancer but also exhibit strong...

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