Central immunological position of the human histo (blood) group O(H).

Peter Arend

Prokaryotic "blood group A/B-like" antigenic structures apparently induce basically cross-reactive anti-A/B immunoglobulins, which due to clonal selection neither arise in blood group A nor in B individuals, and occur exclusively in blood group O. While bacterial endotoxins non-specifically stimulate the formation of all immunoglobulins, most likely involving the anti-A/B isoagglutinins, a definite, adaptive immunological induction of these agglutinins appears to be restricted to blood group O(H) individuals. In the non-O blood groups, anti-A/B reactivity is...

1 Related Work

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
Development of the blood group A phenotype is associated with the impaired formation of adaptive and innate immunoglobulins due to clonal selection and phenotypic, glycosidic accommodation of plasma proteins. Compared with individuals with blood group O(H), individuals with blood group A have a significantly higher risk of developing certain types of cancer and exhibit strong susceptibility to malaria tropica or infection by Plasmodium falciparum. Although malaria tertiana, caused by Plasmodium vivax, is the best documented...

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  • 2017
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