Central immunological position of the human histo (blood) group O(H).

Peter Arend

Prokaryotic "blood group A/B-like" antigenic structures apparently induce basically cross-reactive anti-A/B immunoglobulins, which due to clonal selection neither arise in blood group A nor in B individuals, and occur exclusively in blood group O. While bacterial endotoxins non-specifically stimulate the formation of all immunoglobulins, most likely involving the anti-A/B isoagglutinins, a definite, adaptive immunological induction of these agglutinins appears to be restricted to blood group O(H) individuals. In the non-O blood groups, anti-A/B reactivity is...

1 Related Work

Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease.

Peter Arend
The human ABO(H) blood phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but arise in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with the impaired formation of adaptive and innate immunoglobulin specificities. Indeed, compared with individuals with blood group O(H), individuals with blood group A not only have significantly higher risk of developing certain types of cancer but also exhibit strong...

Publication Year

  • 2017
    1

Data Centers

  • figshare Academic Research System
    1