Central immunological position of the human histo (blood) group O(H).

Peter Arend

Prokaryotic "blood group A/B-like" antigenic structures apparently induce basically cross-reactive anti-A/B immunoglobulins, which due to clonal selection neither arise in blood group A nor in B individuals, and occur exclusively in blood group O. While bacterial endotoxins non-specifically stimulate the formation of all immunoglobulins, most likely involving the anti-A/B isoagglutinins, a definite, adaptive immunological induction of these agglutinins appears to be restricted to blood group O(H) individuals. In the non-O blood groups, anti-A/B reactivity is...

1 Related Work

Central immunological position of the human histo (blood) group O(H) phenotype.

Peter Arend
Abstract: Blood group A phenotype development is associated with impaired formation of adaptive and innate immunoglobulins due to clonal selection and phenotypic, glycosidic accommodation of plasma proteins. Moreover, it is significantly burdened with an increased risk of developing different types of cancer, while exerting strong susceptibility to severe malaria infection. Both the risk of developing cancer and susceptibility to malaria disease appear molecularly to be strongly related to phenotype formation, in which the blood group...

Resource Types

  • Text
    1

Publication Year

  • 2017
    1

Data Centers

  • figshare Academic Research System
    1