Harmonizing Optimized Designs With Classic Randomization in Experiments

Adam Kapelner, Abba M. Krieger, Michael Sklar, Uri Shalit & David Azriel
There is a long debate in experimental design between the classic randomization design of Fisher, Yates, Kempthorne, Cochran, and those who advocate deterministic assignments based on notions of optimality. In nonsequential trials comparing treatment and control, covariate measurements for each subject are known in advance, and subjects can be divided into two groups based on a criterion of imbalance. With the advent of modern computing, this partition can be made nearly perfectly balanced via numerical...
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