Harmonizing Optimized Designs with Classic Randomization in Experiments

Adam Kapelner, Abba M. Krieger, Michael Sklar, Uri Shalit & David Azriel
There is a long debate in experimental design between the classic randomization design of Fisher, Yates, Kempthorne, Cochran and those who advocate deterministic assignments based on notions of optimality. In non-sequential trials comparing treatment and control, covariate measurements for each subject are known in advance, and subjects can be divided into two groups based on a criterion of imbalance. With the advent of modern computing, this partition can be made nearly perfectly balanced via numerical...
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