Base promoted synthesis of 3-benzyl-2,5-diarylpyrazines from arylaldehydes and α-amino ketones

Chao Wang
A novel approach to 3-benzyl-2,5-diarylpyrazine derivatives from α-amino ketones hydrochloride and arylaldehydes in the presence of Na2CO3 has been developed. In contrast with the classic synthetic methods of pyrazines, this protocol does not need additional oxidants and is more friendly to environment.
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