Integrated analysis of miRNA and mRNA expression profiles in p53-edited PFF cells
Chuanmin Qiao, Weiwei Liu, Haoyun Jiang, Maozhang He, Qiang Yang & Yuyun Xing
p53 is the most frequently mutated gene in human cancers, with over half of all tumors harboring mutation at this locus. R248 and R249 (corresponding to porcine R241 and R242), are among the hotspot mutations frequently mutated in liver, lung, breast, and some other cancers. In this study, p53 gene was knocked out or point-edited (R241 and R242 were converted to 241W and 242S) in porcine fetal fibroblast (PFF) cells via CRISPR-Cas9 technique. High throughput...
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