Gain of function mutant p53 protein activates AKT through the Rac1 signaling to promote tumorigenesis

Xuetian Yue, Fangnan Wu, Yanchen Li, Juan Liu, Michael Boateng, Kranthi Mandava, Cen Zhang, Zhaohui Feng, Jimin Gao & Wenwei Hu
Tumor suppressor p53 is the most frequently mutated gene in human cancer. Mutant p53 (mutp53) not only loses the tumor suppressive activity of wild type p53, but often gains new oncogenic activities to promote tumorigenesis, defined as mutp53 gain of function (GOF). While the concept of mutp53 GOF is well-established, its underlying mechanism is not well-understood. AKT has been suggested to be activated by mutp53 and contribute to mutp53 GOF, but its underlying mechanism is...
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