Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow

Lin Wang, Li Yan, Jieling Jiang, Yuyi Zhang, Qiyu He, Hui Zhuang & Ling Wang
Hepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and/or viral proteins were persistently detected in the bone marrow of both patients. The finding suggests that HEV can replicate in human bone marrow as it may serve as a new target site...
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