Synthesis and Evaluation of Coumarin–Resveratrol Hybrids as 15-Lipoxygenaze Inhibitors

Samira Rahmani-Nezhad, Leila Khosravani, Mina Saeedi, , , , , Hamid Nadri, , Mohammad Mahdavi, Abbas Shafiee &
A series of coumarin–resveratrol hybrids, 3-arylcoumarin derivatives 3a–u, were synthesized through the intermolecular condensation reaction of various salicylaldehydes and phenylacetic acids in the presence of 1,4-diazabicyclo[2.2.2]octane under solvent-free conditions. All the synthesized compounds were screened for their inhibitory potency against soybean 15-lipoxygenase. Among them, three compounds (3c, 3j, and 3q) showed good enzyme-inhibitory activities.
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