Acute reproductive toxicology after intratesticular injection of silver nanoparticles (AgNPs) in Wistar rats

Juliana Lis Mendes De Brito, Vanessa Nicolau De Lima, , Sergio Enrique Moya, Paulo Cesar Morais, Ricardo Bentes De Azevedo & Carolina Madeira Lucci
This study aimed to evaluate the effects of an intratesticular injection of silver nanoparticles (AgNPs) on reproductive parameters and health of rats, and to evaluate the AgNPs biodistribution in order to develop a nanotechnological contraceptive agent for male animals. Treated animals received 220 μL of AgNPs solution (0.46 µg-Ag/ml) in each testicle and were euthanized: seven, 14, 28, and 56 days after injection. A significant decrease (p p p
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