Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect

Man Xu, Guangmeng Li, Haoxiang Zhang, Xiaoming Chen, Yi Li, Qianming Yao & Maobin Xie
To improve synergistic anticancer efficacy and minimize the adverse effects of chemotherapeutic drugs, temozolomide (TMZ) and curcumin (CUR) co-loaded nanostructured lipid carriers (NLCs) were prepared by microemulsion in this study. And the physicochemical properties, drug release behavior, intracellular uptake efficiency, in vitro and in vivo anticancer effects of TMZ/CUR-NLCs were evaluated. TMZ/CUR-NLCs showed enhanced inhibitory effects on glioma cells compared to single drug loaded NLCs, which may be owing to that the quickly released CUR...
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