A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods

Haowen Li, Yijing Li, Hui Ao, Jingxin Fu, Yifei Guo, Meihua Han, Xueying Yan, Xi Chen & Xiangtao Wang
Icaritin (ICT) and hydrous icaritin (HICT) are two similar flavonoids compounds isolated from Epimedium Genus. This is the first comparative study on their in vitro and in vivo antitumor effects. Nanorods (NRs) were prepared for ICT and HICT by anti-solvent precipitation method using D-alpha tocopherol acid polyethylene glycol succinate (TPGS) as a stabilizer. The prepared ICT-NRs and HICT-NRs had similar diameter (155.5 nm and 201.7 nm), high drug loading content (43.30 ± 0.22% and 41.08...
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