Correlation between myocardial strain and adverse remodeling in a non-diabetic model of heart failure following empagliflozin therapy

Alvaro Garcia-Ropero, Carlos G. Santos-Gallego, Ariana P. Vargas-Delgado, Juan Antonio Requena-Ibanez, , Kiyotake Ishikawa, Javier Sanz, Jose Tunon & Juan J. Badimon
The sodium-glucose cotransporter type 2 inhibitors reduce mortality and heart failure (HF) hospitalizations. The underlying mechanisms remain unclear but seem to be irrespective of glucose-lowering properties. This study aims to evaluate the impact of empagliflozin on myocardial biomechanics and correlation with markers of adverse remodeling. Following myocardial infarct induction to create a model of HF, 14 pigs were randomly assigned in a 1:1 ratio to receive either empagliflozin 10 mg daily or placebo for 2...
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