Ezrin is essential for the entry of Japanese encephalitis virus into the human brain microvascular endothelial cells

Yan-Gang Liu, Yang Chen, Xiaohang Wang, Ping Zhao, Yongzhe Zhu & Zhongtian Qi
Japanese encephalitis virus (JEV) remains the predominant cause of viral encephalitis worldwide. It reaches the central nervous system upon crossing the blood–brain barrier through pathogenic mechanisms that are not completely understood. Here, using a high-throughput siRNA screening assay combined with verification experiments, we found that JEV enters the primary human brain microvascular endothelial cells (HBMEC) through a caveolae-mediated endocytic pathway. The role of ezrin, an essential host factor for JEV entry based on our screening,...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.