Lectin recognition and hepatocyte endocytosis of GalNAc-decorated nanostructured lipid carriers

Laura Gauthier, Mireille Chevallet, , Michel Thépaut, Pascale Delangle, Franck Fieschi, Corinne Vivès, Isabelle Texier, Aurélien Deniaud & Christelle Gateau
Liver is the main organ for metabolism but is also subject to various pathologies, from viral, genetic, cancer or metabolic origin. There is thus a crucial need to develop efficient liver-targeted drug delivery strategies. Asialoglycoprotein receptor (ASGPR) is a C-type lectin expressed in the hepatocyte plasma membrane that efficiently endocytoses glycoproteins exposing galactose (Gal) or N-acetylgalactosamine (GalNAc). Its targeting has been successfully used to drive the uptake of small molecules decorated with three or four...
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