Supplementary Material for: A Bayesian Hierarchical Framework for Pathway Analysis in Genome-Wide Association Studies

L. Zhang, C. Papachristou, P.K. Choudhary & S. Biswas
Background: Pathway analysis allows joint consideration of multiple SNPs belonging to multiple genes, which in turn belong to a biologically defined pathway. This type of analysis is usually more powerful than single-SNP analyses for detecting joint effects of variants in a pathway. Methods: We develop a Bayesian hierarchical model by fully modeling the 3-level hierarchy, namely, SNP-gene-pathway that is naturally inherent in the structure of the pathways, unlike the currently used ad hoc ways of...
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