SARS-CoV-2 spike produced in insect cells elicits high neutralization titres in non-human primates

Tingting Li, Qingbing Zheng, Hai Yu, Dinghui Wu, Wenhui Xue, Hualong Xiong, Xiaofen Huang, Meifeng Nie, Mingxi Yue, Rui Rong, Sibo Zhang, Yuyun Zhang, Yangtao Wu, Shaojuan Wang, Zhenghui Zha, Tingting Chen, Tingting Deng, Yingbin Wang, Tianying Zhang, Yixin Chen, Quan Yuan, Qinjian Zhao, Jun Zhang, Ying Gu, Shaowei Li … & Ningshao Xia
The current coronavirus disease 2019 (COVID-19) pandemic was the result of the rapid transmission of a highly pathogenic coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), for which there is no efficacious vaccine or therapeutic. Toward the development of a vaccine, here we expressed and evaluated as potential candidates four versions of the spike (S) protein using an insect cell expression system: receptor binding domain (RBD), S1 subunit, the wild-type S ectodomain (S-WT), and the...
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