Robust RNA-seq data analysis using an integrated method of ROC curve and Kolmogorov–Smirnov test

Shengping Yang, Kun Zhang & Zhide Fang
It is a common approach to dichotomize a continuous biomarker in clinical setting for the convenience of application. Analytically, results from using a dichotomized biomarker are often more reliable and resistant to outliers, bi-modal and other unknown distributions. There are two commonly used methods for selecting the best cutoff value for dichotomization of a continuous biomarker, using either maximally selected chi-square statistic or a ROC curve, specifically the Youden Index. In this paper, we explained...
1 citation reported since publication in 2020.
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