Identification of curcumin as a novel natural inhibitor of rDNA transcription

Yinfeng Xu, Yaosen Wu, Lei Wang, Chuying Qian, Qian Wang & Wei Wan
Ribosomal DNA (rDNA) transcription drives cell growth and cell proliferation via the product ribosomal RNA (rRNA), the essential component of ribosome. Given the fundamental role of rRNA in ribosome biogenesis, rDNA transcription has emerged as one of the effective targets for a number of human diseases including various types of cancers. In this study, we identify curcumin, an ancient drug, as a novel natural inhibitor of rDNA transcription. Curcumin treatment impairs the assembly of the...
1 citation reported since publication in 2020.
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