Vagus nerve plays a pivotal role in CD4+ T cell differentiation during CVB3-induced murine acute myocarditis

Li Yue-Chun, Xiao-Hong Gu, Ge Li-Sha, De-Pu Zhou, Chao Xing, Xiao-Ling Guo, Lu-Lu Pan, Shi-Yang Song, Li-Li Yu, Guang-Yi Chen, Jia-Feng Lin & Mao-Ping Chu
Abnormalities in CD4+ T cell (Th cell) differentiation play an important role in the pathogenesis of viral myocarditis (VMC). Our previous studies demonstrated that activation of the cholinergic anti-inflammatory pathway (CAP) alleviated the inflammatory response. In addition, we observed that right cervical vagotomy aggravates VMC by inhibiting CAP. However, the vagus nerve’s effect on differentiation of CD4+ T cells has not been studied in VMC mice to date. In this study, we investigated the effects...
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