Acute Radiation Syndrome-related gene expression in irradiated peripheral blood cell populations

Patrick Ostheim, Alan Don Mallawaratchy, Thomas Müller, Simone Schüle, Cornelius Hermann, Tanja Popp, Stefan Eder, Stephanie E. Combs, Matthias Port & Michael Abend
In a nuclear or radiological event, an early diagnostic or prognostic tool is needed to distinguish the worried well from low-exposed and those individuals who may later develop life-threatening hematologic acute radiation syndrome (H-ARS). In previous studies, we identified and validated genes in peripheral blood for this purpose. To gain a deeper understanding and to make methodological improvements, we examined the contribution of the peripheral blood´s cell populations on radiation-induced gene expression changes. EDTA whole...
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