Effects of the histone acetylase inhibitor C646 on growth and differentiation of adipose-derived stem cells

Zhimin Wang, Xiao Wang, Meiyu Bi, Xiao Hu, Qing Wang, Hao Liang & Dongjun Liu
As an important histone acetylase, the transcriptional coactivator P300/CBP affects target gene expression and plays a role in the maintenance of stem cell characteristics and differentiation potential. In this study, we explored the action of a highly effective selective histone acetylase inhibitor, C646, on goat adipose-derived stem cells (gADSCs), and investigated the impact of histone acetylation on the growth characteristics and the differentiation potential of ADSCs. We found that C646 blocked the cell proliferation, arrested...
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