A novel irinotecan-lipiodol nanoemulsion for intravascular administration: pharmacokinetics and biodistribution in the normal and tumor bearing rat liver

Marites P. Melancon, Steven Yevich, Rony Avritscher, Adam Swigost, Linfeng Lu, Li Tian, Jossana A. Damasco, Katherine Dixon, Andrea C. Cortes, Nina M. Munoz, Dong Liang, David Liu & Alda L. Tam
Colorectal cancer is one of the most common cancers in the United States and treatment options are limited for patients who develop liver metastases. Several chemotherapeutic regimens have been used for transvascular liver-directed therapy in the treatment of colorectal liver metastases without clear evidence of superiority of one therapy over another. We describe the development of a novel nanoemulsion through combining irinotecan (IRI), a first line systemic agent used for the treatment of colon cancer,...
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