An epithelial-mesenchymal transition-Related Long Non-Coding RNA signature to predict overall survival and immune microenvironment in Kidney Renal Clear Cell Carcinoma

Yong-Biao Cheng, Sen Li, You-Peng Zhang, Zhao-Hui Zhu & Ning Zhao
Kidney renal clear cell carcinoma (ccRCC) is a malignant tumor originating from renal tubular epithelium, lncRNAs can regulate the occurrence and development of EMT by targeting EMT transcription factors. We constructed a new survival signature based on EMT-related differentially expressed lncRNAs obtained from The Cancer Genome Atlas (TCGA-KIRC). We first determined 1377 EMT-related lncRNAs, lncRNA AL035661.1 with the largest correlation coefficient and the target gene was PFN2 (cor=0.843; P=1.37E-146). Meanwhile, we found an AUC of...
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