Usefulness of candidate mRNAs and miRNAs as biomarkers for mild cognitive impairment and Alzheimer’s disease

Hongyun Qin, Chengping Hu, Xudong Zhao, Ming Tian & Binggen Zhu
To explore potential molecular mechanisms and novel biomarkers of mild cognitive impairment (MCI) and Alzheimer’s disease (AD). The mRNA expression datasets GSE63060 and GSE63061 and the miRNA expression dataset GSE120584 were obtained from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) and miRNA (DEmiRs) were identified in the normal, MCI, and AD groups. Mfuzz clustering and weighted correlation network analyses (WGCNA) were conducted, followed by pathway and functional enrichment analyses and miRNA-mRNA network...
1 citation reported since publication in 2021.
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