Atg9-centered multi-omics integration reveals new autophagy regulators in Saccharomyces cerevisiae

Di Peng, Chen Ruan, Shanshan Fu, Chengwen He, Jingzhen Song, Hui Li, Yiran Tu, Dachao Tang, Lan Yao, Shaofeng Lin, Ying Shi, Weizhi Zhang, Hao Zhou, Le Zhu, Cong Ma, Cheng Chang, Jie Ma, Zhiping Xie, Chenwei Wang & Yu Xue
In Saccharomyces cerevisiae, Atg9 is an important autophagy-related (Atg) protein, and interacts with hundreds of other proteins. How many Atg9-interacting proteins are involved in macroautophagy/autophagy is unclear. Here, we conducted a multi-omic profiling of Atg9-dependent molecular landscapes during nitrogen starvation-induced autophagy, and identified 290 and 256 genes to be markedly regulated by ATG9 in transcriptional and translational levels, respectively. Unexpectedly, we found most of known Atg proteins and autophagy regulators that interact with Atg9 were...
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