Cryptotanshinone possesses therapeutic effects on ischaemic stroke through regulating STAT5 in a rat model

Feihong Zhu, Hehe Chen, Meifei Xu, Xiajun Zhang, Jing Yu, Yali Pan & Weixin Zhu
Cryptotanshinone (CT), a lipophilic compound extracted from roots of Salvia miltiorrhiza Bunge (Lamiaceae) (Danshen), has multiple properties in diseases, such as pulmonary fibrosis, lung cancer, and osteoarthritis. Our previous findings suggest that CT plays a protective role in cerebral stroke. However, the molecular mechanisms underlying CT protection in ischaemic stroke remain unclear. This study examines the effect of CT on ischaemic stroke. We used the middle cerebral artery occlusion (MCAO) rat (Sprague-Dawley rats, 200 ±...
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