Structural insights into dpCoA-RNA decapping by NudC

Wei Zhou, Zeyuan Guan, Fen Zhao, Yage Ye, Fang Yang, Ping Yin & Delin Zhang
Various kinds of cap structures, such as m7G, triphosphate groups, NAD and dpCoA, protect the 5′ terminus of RNA. The cap structures bond covalently to RNA and affect its stability, translation, and transport. The removal of the caps is mainly executed by Nudix hydrolase family proteins, including Dcp2, RppH and NudC. Numerous efforts have been made to elucidate the mechanism underlying the removal of m7G, triphosphate group, and NAD caps. In contrast, few studies related...
1 citation reported since publication in 2021.
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