Potential biomarkers for inherited thrombocytopenia 2 identified by plasma proteomics

Xiaojie Wang, Maoshan Chen, Limeng Dai, Chengning Tan, Lanyue Hu, Yichi Zhang, Yanni Xiao, Fengjie Li, Cheng Zeng, Zheng Xiang, Yali Wang, Weiwei Zhang, Xiaomei Zhang, Qian Ran, Zhongjun Li & Li Chen
Inherited thrombocytopenia 2 (THC2) is difficult to diagnose due to the lack of specific clinical characteristics and diagnostic methods. To identify potential plasma protein biomarkers for THC2, we collected the plasma samples from a THC2 family (9 THC2 and 15 non-THC2 members), enriched the medium and low abundant proteins using Proteominer and analyzed the protein profiles using the liquid chromatography-mass spectrometry in data independent acquisition mode. Initially, we detected 784 proteins in the plasma samples...
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